SBL640
| SBL640 | |
|---|---|
| Biological pathways | |
| Credits | 4 |
| Structure | 3-0-2 |
| Pre-requisites | SBL500 and SBL520 |
| Overlaps | |
SBL640 : Biological pathways
[edit]Lecture: Introduction to energy metabolism; When you get hungry; Regulation of glucose metabolism; Regulation of fat metabolism; Glucose energy homeostasis and diabetes; Extracellular signal and role of receptors; Intracellular receptors of extracellular signals; Signaling proteins can act as molecular switches; Nuclear and transmembrane receptors; Kinases; Protein–protein interactions in signal transduction ; Glucose metabolism: an example of integration of signaling pathways; Intracellular receptors and nuclear receptors; Molecular switches- GTPases; Receptor and non-receptor tyrosine kinases; signaling domains; kinase sensors of metabolism- AMPK, mTOR and beyond; MAPKs and phosphatases; Signaling in migration and chemotaxis; Regulatory rewiring of metabolism in cancer; small molecule modulators of metabolism; Induced pluripotent cells- mechanisms and applications. Laboratory: Monitoring of glycolysis in cultured cells by measurement of glucose uptake and lactate production; effect of external conditions on glycolysis; activity of pyruvate kinase extracted from cells; inhibitors and activators of PK activity; stimulation of signaling pathways by TNF-⍺ and phosphorylation of MAP kinase; effect of concentration and time.