SBL723
| SBL723 | |
|---|---|
| principles of Neural Excitability and Communication | |
| Credits | 3 |
| Structure | 3-0-0 |
| Pre-requisites | |
| Overlaps | |
SBL723 : principles of Neural Excitability and Communication
[edit]Courses of Study 2024-2025 Biological Sciences 353Pre-requisite(s): EC 75 and SBL 100/BBL 131/CML101/ Equivalent Neural physiology overview; Elements of excitable cell membrane: ion channels, transporters and cytoskeletal elements; Physical principles of neuronal excitability: Diffusion, Electro-diffusion, Nernst-Plank Equation, Donnan equilibrium, Goldman-Hodgkin-Katz equation; Concept of Resting membrane potential (RMP), maintenance of RMP-Pumps and transporters; Exemplar pump: Na+-K+ ATPase-structure and function; Pores in the membrane: Ion channels; Hodgkin-Huxley model for Na+ and K+ channels; Action potentials; Ion channel structure, function & modulation; Synaptic transmission: vesicle transport and recycling, neurotransmitter release; Neurotransmitter-receptor structure-function; Methods to study ion channels and receptors: Patch-Clamp, planar-bilayer, crystallography and Cryo-EM studies; Action potential generation and conduction: Mechanism and models; Simulation of neural activity