Prashantt492: Creating course page via bot

2026-03-04T10:23:46Z

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{{Infobox Course
| code = SBL724
| name = Decoding Protein Modifications in Biology
| credits = 3
| credit_structure = 3-0-0
| pre_requisites = EC 75 and SBL100 for UG students
| overlaps =
}}

== SBL724 : Decoding Protein Modifications in Biology ==
Introduction to protein modifications – folded protein versus functional protein, residue modifications, proteolytic processing, transient versus stable modifications, co-translational versus posttranslational modifications, domains decoding protein modifications; Protein phosphorylation – kinases and phosphatases, consequences of phosphorylation; Ubiquitination – ubiquitin proteasomal system, degradative and non-degradative ubiquitination, techniques in ubiquitination research; SUMOylation and other protein conjugation systems; Glycosylation –role in protein structure and function, advanced glycation intermediates, dynamic O-GlcNac modifications; Other protein modifications – acetylation, methylation, lipidation etc.; Pathogen-induced host protein modifications; Generation of antibodies against protein modifications; In silico prediction of protein modifications; Protein modifications in diagnostics and therapy; Omics approaches for modified proteome; Kinase inhibitors as drugs. SBL725 Endocytosis and Intracellular Trafficking 3 Credits 3-0-0) Introduction to endocytosis and intracellular trafficking – Structure, function and dynamics of Clathrin-mediated endocytosis; Clathrin-independent endocytosis; Receptor-mediated endocytosis; Traffic through endocytic and secretory pathway; Regulation of intracellular trafficking by vesicle fusion; Endosomal system and sorting; Biogensis of endosomes and lysosomes; Functions of Rab GTPases in vesicle fusions; Role of SNAREs in phagosome maturation; Modulation of phagosome maturation by intracellular pathogens: Mycobacterium; Legionella; Salmonella etc.; Intracellular trafficking and antigen presentation; Human diseases due to defect in intracellular trafficking: Lysosomal storage disease, Atherosclerosis, Niemann Pick C Diseases, Cancers, Neurodegeneration; Exploiting and endocytosis for nanomedicine. SBL726 Biological Motors 3 Credits 3-0-0) Introduction to molecular motors and biological motor proteins, historical perspectives, basics principles and broad functions; Polymerization motors: actin, tubulin and intermediary filaments- their structure-function, dynamics – from in-vivo and in-vitro studies and regulation; Force generators: Myosins, dyneins and Kinesisn – their structure-function and reulation. Rotational motors – FoF1ATP synthase and bacterial flagella (structure and function). Eukaryotic Cilia/flagella; DNA helicase and polymerase; Viral assembly – with specific examples of bacteriophages and retroviruses; recent advance (research articles) on organelle transport; Nuclear motors; Molecular motors associated with disease – with emphasis on myosin, dynein and kinesin; Methodologies used to study biological motor proteins; Biological motors in futuristic design. SBL727 Advanced Developmental Biology 3 Credits 3-0-0)Pre-requisite(s): EC 75 and

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